Effects of long-term etanercept treatment on anxiety- and depression-like neurobehaviors in rats

Bayramgürler D., Karson A., Özer C., Utkan T.

PHYSIOLOGY & BEHAVIOR, vol.119, pp.145-148, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 119
  • Publication Date: 2013
  • Doi Number: 10.1016/j.physbeh.2013.06.010
  • Journal Name: PHYSIOLOGY & BEHAVIOR
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.145-148
  • Keywords: Etanercept, Inflammation, TNF-alpha, Forced swimming, Elevated plus maze, NECROSIS-FACTOR-ALPHA, INDUCED-SICKNESS BEHAVIOR, RHEUMATOID-ARTHRITIS, PSORIASIS, CYTOKINES, STRESS, MICE, INTERLEUKIN-1-BETA, INFLIXIMAB, BUPROPION
  • Kocaeli University Affiliated: Yes

Abstract

Growing evidence indicates that there is a correlation between depression and inflammation. Administration of anti-tumor necrosis factor (TNF) agents for treatment of chronic inflammatory diseases, such as psoriasis, was associated with decreased depressive symptoms and increased quality of life in some clinical studies. The aim of the present study was to investigate the effects of chronic etanercept, a TNE-alpha inhibitor, on anxiety- and depression-like neurobehaviors in rats.