Investigation on the mechanism involved in the effects of agmatine on ethanol-induced gastric mucosal injury in rats

Utkan T. , Ulak G. , Yildiran H. G. , Yardimoglu M. , Gacar M. N.

LIFE SCIENCES, cilt.66, ss.1705-1711, 2000 (SCI İndekslerine Giren Dergi) identifier identifier identifier


Effects of agmatine, an endogenous metabolite formed by decarboxylation of L-arginine, on ethanol-induced gastric mucosal injury were investigated in rats. Agmatine at 1 and 10 mg/kg i.p doses significantly increased ethanol-induced gastric mucosal injury. This effect of agmatine was abolished completely by pretreatment with idazoxan, an imidazoline receptor-antagonist and alpha(2) receptor- antagonist, (0.5 mg/kg i.p), partly by yohimbine, an alpha(2) receptor- antagonist, (1 mg/kg i.p) but not by L-arginine, a precursor of nitric oxide, (500 mg/kg i.p). Our results suggest that agmatine had a potent ulcerogenic effect mediated, at least in part, by both alpha(2)-adrenoceptors and imidazoline receptors.