Akademik Veri Yönetim Sistemi
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING, cilt.27, sa.11, ss.2284-2293, 2019 (SCI-Expanded)
Epileptic seizures occur as a result of a process that develops over time and space in epileptic networks. In this study, we aim at developing a generalizable method for patient-specific seizure prediction by evaluating the spatio-temporal correlation in the features obtained from multichannel EEG signals. Spectral band power, statistical moment and Hjorth parameters are used to reveal the frequency and time domain features of the EEG signals. The features are given as input to a convolutional neural network (CNN) by transforming into a sequence of multi-color images according to the topology of the EEG channels. The multi-frame 3D CNN model is proposed to evaluate the temporal and spatial correlation in training data collectively. The proposed 3D CNN model achieves a sensitivity of 85.7%, a false prediction rate of 0.096/h, and a proportion of time-in-warning of 10.5%, in the tests performed with 16 patients from the CHB-MIT scalp EEG dataset. The results show that the superiority of the proposed method to a Poisson based random predictor was statistically significant for 93.7% of the patients, at significance level of 0.05. Our experiments with various timing constraints show that epileptic stage lengths are an important factor affecting seizure performance. We present a subject-specific seizure prediction method that is robust for unbalanced data and can be generalized to any scalp EEG dataset without the need for subject-specific engineering.