Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways

Ilbey, Yusuf; Ozbek, Emin; Cekmen, Mustafa; Simsek, Abdulmuttalip; Otunctemur, Alper; Somay, Adnan

doi:10.1093/humrep/dep058

Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways

Ilbey Y. O., Ozbek E., Cekmen M., Simsek A., Otunctemur A., Somay A.

HUMAN REPRODUCTION, vol.24, no.7, pp.1717-1725, 2009 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 24 Issue: 7
Publication Date: 2009
Doi Number: 10.1093/humrep/dep058
Journal Name: HUMAN REPRODUCTION
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1717-1725
Open Archive Collection: AVESIS Open Access Collection
Kocaeli University Affiliated: Yes

Abstract

The aim of this study was to investigate the cellular/biochemical mechanisms by which cisplatin (CIS) causes testicular toxicity. We evaluated the role of inducible nitric oxide synthase (iNOS) expression, mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kB) activation in the pathogenesis of testicular damage induced by CIS, and investigated the effects of curcumin (CMN) against CIS-induced testicular injury in rats.