Protective effect of Eisenia foetida coelomic fluid against oxidative damage in human endothelial cells

Kilciler Y., Ozkan A. D., BETTS Z.

TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY, cilt.104, sa.2, ss.307-320, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 104 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/02772248.2022.2137165
  • Dergi Adı: TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, Compendex, Environment Index, Food Science & Technology Abstracts, Geobase, Greenfile, Metadex, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.307-320
  • Anahtar Kelimeler: Eisenia foetida, coelomic fluid, protective effect, oxidative stress, ephitelial cell, toxicity, STRESS
  • Kocaeli Üniversitesi Adresli: Evet

Özet

The protective effect of Eisenia foetida coelomic fluid on hydrogen peroxide-induced oxidative damage and cell death was determined at gene and protein levels. The coelomic fluid protects viability and cell morphology in human umbilical vein endothelial cells, and decreases reactive oxygen species production and apoptotic cells and increases anti-oxidative gene and protein expressions. Eisenia foetida coelomic fluid is potentially a therapeutic candidate for drug development.