Effect of nitric oxide synthase inhibitors in acute lung injury due to blunt lung trauma in rats

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Akgul A. G., ŞAHİN D., Temel U., ELİÇORA A., Dillioglugil M. Ö., Kir H., ...More

TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, vol.27, no.1, pp.63-72, 2019 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 27 Issue: 1
• Publication Date: 2019
• Doi Number: 10.5606/tgkdc.dergisi.2019.15936
• Journal Name: TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.63-72
• Keywords: Acute lung injury, oxidative stress, trauma, PULMONARY CONTUSION, N-ACETYLCYSTEINE, CHEST TRAUMA, L-NAME, ACID, ANTIOXIDANT, MACROPHAGE, MODEL, RESUSCITATION, PATHOGENESIS
• Kocaeli University Affiliated: Yes

Abstract

Background: This study aims to investigate the effects of blunt lung trauma performed in experimental rat model on lung tissue and blood as well as proinflammatory cytokines, oxidant-antioxidant enzymes and histopathological parameters after Ngamma-nitro-L-arginine methyl ester and N-iminoethyl-L-ornithine administration.