Comparison of Deksmedetomidin and Propofol Effects During Flexible Fiberoptic Bronchoscopy
EURASIAN JOURNAL OF PULMONOLOGY, cilt.11, sa.3, ss.115-120, 2009 (ESCI)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 11 Sayı: 3
- Basım Tarihi: 2009
- Dergi Adı: EURASIAN JOURNAL OF PULMONOLOGY
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
- Sayfa Sayıları: ss.115-120
- Kocaeli Üniversitesi Adresli: Evet
Özet
Aim: Eventough flexible fiberoptic bronchoscopy (FFB) is performed under local anesthesia, patients frequently complain of cough, pain and sensation of asphyxiation. Propofol supply a good sedation level, hemodynamic stability, amnesia and quick recovery. Dexmedetomidine is a centrally effective a(2) adrenoreceptor agonist, it provides amnesia and analgesia without respiratory depression. The effects of dexmedetomidine and propofol usage during FFB on amnezia, tolerance and patient satisfaction are compared in this study. Material and methods: Thirty patients undergoing diagnostic FFB were included in this prospective, randomized, double-blind study.. Patients were assigned to have either Grup D (dexmedetomidine n=15) or Grup P (propofol, n=15). The level of the sedation was adjusted to reach Ramsey sedation score 3. At the end of FFB, patients were first interrogated by the anesthezist and then by the bronchoscopist, about amnesia, tolerance and patient satisfaction for FFB. Results: Demographic data, pulmonary function tests, diagnostic procedures, systolic and diastolic BP during FFB procedure and duration of recovery room staying were similar between two groups (p>0.05). Heart rate was lower and SO2 was higher in group D compared to group P but these differences were not statistically significant (p>0.05). In comparison of the groups, both dexmedetomidine and propofol shown similar effects on amnesia, tolerance (pain, cough, sensation of asphyxiation) and patient acceptance. One patient in Group P was desaturated during study, but peripheral oxygen saturation increased to baseline values with increasing oxygen supply. Conclusion: Both propofol and dexmedetomidine had similar effects in cardiovascular and respiratory system, on amnesia, analgesia, cough, sensation of asphyxiation and pain during sedation on FFB. If sedation is preferred during FFB, dexmedetomidine can be used as an alternative to propofol.