Akademik Veri Yönetim Sistemi
MAS 14th International European Conference On Mathematics, Engineering, Natural & Medical Sciences March 26-28, 2021, Budapest, Macaristan, 26 - 28 Mart 2021, ss.245-248
Labial salivary gland biopsy is a widely used and highly effective technique for diagnosis of Sjögren's
syndrome(SS),lymphoma,sarcoidosis,and amyloidosis.SS is one of most common systemic autoimmune
rheumatic diseases,histopathologically characterized by acinar atrophy,lymphocytic infiltration with the
germinal center,and interstitial fibrosis.If a minor salivary gland biopsy is taken,epimyoepithelial islands are
not visible.But it can be seen in the major salivary gland.Classification has been proposed by the American-
European Consensus Group for the diagnosis of Sjögren's syndrome.One of the 6 criteria is detection of focal
lymphocytic sialoadenitis(focus score ≥1 at 4 mm2)by biopsy.According to this consensus, a positive
morphological finding is essential for diagnosis of SS in absence of anti-Ro / SSA antibodies.Biopsies from
SS patients are important for a greater understanding of heterogeneity of immune cell infiltration and
organization within the salivary glands.Relationship of this biopsy with clinical symptoms of disease is
important for the early detection of more severe extraglandular symptoms,lymphoepithelial lesions or
lymphoma.Rationale in this study is to correlate pathological findings with clinical data.Clinic and pathology
reports of salivary gland biopsies performed at our institute from January 2017 to December 2018 were
retrospectively reviewed.There were 143 biopsies in total with clinical suspicion for SS.Patients were between
the ages of 15-79 and 131 (91.6%) were women.There were 50 patients with score ≥3 on Chisholm-Mason
scale.Few patients confirmed diagnostic criteria for SS prior to salivary gland biopsy.In accordance with
literature,this number also increased in our cases according to biopsy results.Sjögren's syndrome is a systemic
autoimmune disease characterized by keratoconjunctivitis sicca, xerostomia,rheumatoid arthritis,and
hypergammaglobulinemia.Thyroid,blood vessels,lung, kidney,liver,lymph nodes,bone marrow,skeletal
muscle and skin may also be involved.It is 9 times more common in women.Average age of onset is between
40-60.Since it may be associated with MALT lymphoma,diagnosis is important.Positive results increase with
biopsy,so it is necessary to take biopsy from all cases with clinical suspicion of SS.