The overall performance of hollow clay tile infilled reinforced concrete (RC) frames strengthened with carbon fiber-reinforced polymer (CFRP) materials is experimentally investigated in this paper For this purpose, five one-third scale, one-bay, two-story specimens were constructed with common deficiencies (that is, low concrete strength, insufficient lap splice length, poor confinement, and lack of joint reinforcement) observed in existing RC frames and tested under reversed cyclic lateral loading. The test results indicated that the investigated strengthening schemes yielded a significant enhancement in both the response and the load capacity. It is also seen that the effectiveness of the strengthening strongly depends on the composite action of the infill panel, ensuring that the surface-bonded fiber-reinforced polymer (FRP) is provided with a sufficient anchorage development length to the surrounding frames. Results and discussions are presented on the basis of the observed global performance and local failure mechanisms along with the detailed comparisons of similar studies. Conclusions are also drawn to provide tentative retrofit FRP scheme recommendations.