Akademik Veri Yönetim Sistemi
NEUROLOGY ASIA, cilt.26, sa.2, ss.341-346, 2021 (SCI-Expanded)
Background & Objective: Multiple Sclerosis (MS) is an inflammatory, demyelinating and degenerative disease of the central nervous system. To determine the extent of disability and loss of functions, we used the Expanded Disability Status Scale (EDSS), Timed 25 Foot Walk Test (T25-FW), 9-Hole Peg Test (9-HFT), Symbol Digit Modalities test (SDMT) and the Montreal Cognitive Assessment Test (MOCA). In this study, we focused on the effects of cerebellar volume and the correlation between cerebellar atrophy and functional test results. Methods: We retrospectively recruited 58 MS patients and 30 healthy controls. Cranial magnetic resonance imaging (MRI) and functional tests were obtained from all subjects. Duration between clinical tests and MRI acquisition was no longer than two weeks. Volumetric MRI evaluation was performed with the volBrain automatic segmentation pipeline. Results were analyzed by t-test and Spearman correlation analysis to determine the relationship between variables and to compare the two groups. Results: Mean values for age (p=0.351) and distribution in gender (p=0.8.34) were similar for patients and controls. Mean disease duration in patients was 5.85 +/- 5.45 years. Mean values for cerebellar volume and normalized cerebellar volume were significantly reduced in patients compared to controls (p=0.036 and p=0.022, respectively). Cerebellar volumes were significantly correlated with the results of the SDMT, MOCA and timed T25-FW tests.