The associations between caffeine treatment and common preterm morbidities: a retrospective cohort analysis

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Yavanoglu Atay F., Kanmaz Kutman H. G., Bidev D., Bozkurt Kalyoncu Ö., Oğuz Ş. S.

FRONTIERS IN PEDIATRICS, cilt.11, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11
  • Basım Tarihi: 2023
  • Doi Numarası: 10.3389/fped.2023.1178976
  • Dergi Adı: FRONTIERS IN PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals
  • Anahtar Kelimeler: bronchopulmonary dysplasia, caffeine, morbidity, preterm, respiratory distress
  • Kocaeli Üniversitesi Adresli: Evet

Özet

IntroductionCaffeine is one of the most used drugs in the neonatal intensive care units (NICUs). It is widely regarded as beneficial in preventing many morbidities by reducing apnea of prematurity and improving respiratory functions. MethodsPremature infants with gestational ages >25 and ResultsA total of 475 patients were analyzed. The patients receiving caffeine were classified as Group 1 (n = 355), and the patients not receiving caffeine were classified as Group 2 (n = 120). Despite the higher incidence of respiratory distress syndrome requiring surfactant therapy and a longer duration of respiratory support in Group 2, the rates of bronchopulmonary dysplasia (BPD) and most other common morbidities were quite comparable. The frequency of apnea was statistically lower in the group that received caffeine prophylaxis (p < 0.01). ConclusionIn this retrospective cohort analysis, we found that caffeine prophylaxis significantly decreased apnea attacks however does not prevent respiratory morbidity such as BPD.