In vivo confocal microscopy of corneal nerve fiber damage in early course of multiple sclerosis

Toprak M., ALTINTAS O., Bickin H., EFENDİ H., YILMAZ TUĞAN B., YÜKSEL N.

INTERNATIONAL OPHTHALMOLOGY, cilt.43, sa.2, ss.503-509, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 2
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s10792-022-02448-6
  • Dergi Adı: INTERNATIONAL OPHTHALMOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.503-509
  • Anahtar Kelimeler: In vivo confocal microscopy, Multiple sclerosis, Corneal nerve fiber density, Corneal nerve branch density, Corneal nerve fiber tortuosity, DEGENERATION
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Purpose To evaluate the corneal nerve fiber morphology in patients with multiple sclerosis (MS) by in vivo corneal confocal microscopy (CCM). Methods Retinal nerve fiber layer thickness (RNFLT), central macular thickness (CMT), corneal nerve fiber length (CNFL), corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD) and corneal nerve fiber tortuosity (CNFT) were measured. Correlation of corneal nerve findings with duration and clinical severity of MS was calculated. Results CNFL (9.50 +/- 0.60 vs. 11.20 +/- 0.57 mm/mm(2), P = 0.046) and CNBD (57.46 +/- 5.04 vs. 77.65 +/- 3.41 no/mm(2), P = 0.001) were significantly lower with no significant difference in CNFD (21.24 +/- 1.20 vs. 23.62 +/- 0.95 no/mm(2), P = 0.125), CNFT (2.00 +/- 0.15 vs. 1.73 +/- 0.12, P = 0.180), CMT (269.57 +/- 12.53 vs. 271.10 +/- 18.84 mu m, P = 0.716) or RNFLT (102.82 +/- 6.98 vs. 105.33 +/- 12.70 mu m, P = 0.351) between patients with RRMS compared to controls. There was no significant correlation between CCM parameters with EDSS and duration of disease in MS patients. Conclusion The current study demonstrated that a decrease in CNFL, CNFD and CNBD in CCM analysis in the early course of MS.