Protective effect of nebivolol on gentamicin-induced nephrotoxicity in rats

Dursun, M.; Sahin, S.; Besiroglu, H.; Otunctemur, A.; Ozbek, E.; Cakir, S.; Cekmen, M.; Somay, A.

doi:10.4149/bll_2018_128

Protective effect of nebivolol on gentamicin-induced nephrotoxicity in rats

Atıf İçin Kopyala

Dursun M., Sahin S., Besiroglu H., Otunctemur A., Ozbek E., Cakir S. S., ...Daha Fazla

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, cilt.119, sa.11, ss.718-725, 2018 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 119 Sayı: 11
Basım Tarihi: 2018
Doi Numarası: 10.4149/bll_2018_128
Dergi Adı: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.718-725
Kocaeli Üniversitesi Adresli: Hayır

Özet

OBJECTIVE: Nephrotoxicity is a major complication of gentamicin (GEN), which is widely used in the treatment of severe Gram-negative infections. As we know, treatment with nebivolol has been shown to decrease renal fibrosis and glomerular injury as well as improve endothelial dysfunction. Therefore, we evaluated the potential protective effect of nebivolol (NBV) against GEN-induced nephrotoxicity in rats.