Electron ionization induced fragmentation of some oxadiazole and thiadiazole derivatives


Pihlaja K., Agirbas H., Ovcharenko V., Valtamo P.

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol.18, pp.760-764, 2004 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 7
  • Publication Date: 2004
  • Doi Number: 10.1002/rcm.1397
  • Title of Journal : RAPID COMMUNICATIONS IN MASS SPECTROMETRY
  • Page Numbers: pp.760-764

Abstract

The mass spectrometric behaviour under electron ionization of several 3,4-(alkyl/aryl)-disubstituted 1,2,4-oxadiazole-5(4H)-ones (1-13) and 1,2,4-thiadiazole-5(4H)-thiones (14-17), and that of 3-aryl-5-alkyl- or arylthio-1,2,4-thiadiazoles (18-24), was studied. These five-membered rings split similarly to the corresponding 1,2,4-thiadiazole-5(4H)-ones, although substitution has also a clear effect on the routes of fragmentation and the magnitude of secondary processes. In particular, the fragmentation of 1,2,4-oxadiazole-5(4H)-ones (1-6), which do not bear aromatic substituents, was, in addition to the ring ruptures, fairly complicated. The other compounds fragmented more systematically and relatively few unpredictable fragmentations occurred. Copyright (C) 2004 John Wiley Sons, Ltd.