Immunocytochemistry of neuron specific enolase (NSE) in the rat brain after single and repeated epileptic seizures
INTERNATIONAL JOURNAL OF NEUROSCIENCE, cilt.118, sa.7, ss.981-993, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 118 Sayı: 7
- Basım Tarihi: 2008
- Doi Numarası: 10.1080/00207450701769232
- Dergi Adı: INTERNATIONAL JOURNAL OF NEUROSCIENCE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.981-993
- Anahtar Kelimeler: epileptic seizure, neuron specific enolase, nissl, pentylenetetrazol, rat brain, TEMPORAL-LOBE EPILEPSY, CEREBROSPINAL-FLUID, S-100 PROTEIN, KAINIC ACID, DAMAGE, MARKER, INCREASES, HIPPOCAMPUS, EXPRESSION, AUTOPSIES
- Kocaeli Üniversitesi Adresli: Evet
Özet
The aim of this study was to investigate neuron-specific enolase (NSE) immunoreactivity of the different brain regions after pentylenetetrazol (PTZ)- induced epileptic seizures in rats. Light microscopic examinations provided evidences for changes of neuronal activity after single and repeated seizures. The number of NSE (+) cells was well correlated with Nissl staining. The results suggest that NSE immunoreactivity may be a valuable marker for determination of the number of metabolically active neurons in different brain regions after single and repeated experimental seizures.