Immunocytochemistry of neuron specific enolase (NSE) in the rat brain after single and repeated epileptic seizures

Yardimoglu M. , Ilbay G. , DALÇIK C., DALÇIK H., ŞAHİN D. , ATEŞ N.

INTERNATIONAL JOURNAL OF NEUROSCIENCE, cilt.118, ss.981-993, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 118 Konu: 7
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1080/00207450701769232
  • Sayfa Sayıları: ss.981-993


The aim of this study was to investigate neuron-specific enolase (NSE) immunoreactivity of the different brain regions after pentylenetetrazol (PTZ)- induced epileptic seizures in rats. Light microscopic examinations provided evidences for changes of neuronal activity after single and repeated seizures. The number of NSE (+) cells was well correlated with Nissl staining. The results suggest that NSE immunoreactivity may be a valuable marker for determination of the number of metabolically active neurons in different brain regions after single and repeated experimental seizures.