The population impact of human papillomavirus vaccination on cancer and pre-cancer outcomes: An umbrella review of meta-analyses
HUMAN VACCINES & IMMUNOTHERAPEUTICS, cilt.22, sa.1, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 22 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.1080/21645515.2026.2699584
- Dergi Adı: HUMAN VACCINES & IMMUNOTHERAPEUTICS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE, Directory of Open Access Journals
- Kocaeli Üniversitesi Adresli: Evet
Özet
Despite widespread HPV vaccination, a comprehensive synthesis across populations and cancer outcomes is lacking. This umbrella review evaluates HPV vaccination's population impact on infection, precancerous lesions, and invasive cancers. We searched five databases for meta-analyses reporting prophylactic HPV vaccine outcomes up to Jan 2026. Two reviewers performed selection, data extraction, AMSTAR-2, and GRADE. From 34 meta-analyses, RCTs in HPV-na & iuml;ve women showed 99% efficacy (95% CI: 98-99%) against HPV16/18 infection, 96% against CIN2+, and 89% against anogenital warts. Observational studies found relative risks of 0.12-0.36 (HPV16/18) and 0.48-0.68 (CIN2+). In men, effectiveness against warts was 74-90%. Ecological studies reported reductions in cervical cancer of 57-88%. GRADE certainty was high for infection/warts, moderate for precancer, and low for invasive cancer. HPV vaccination is highly effective. Invasive cancer prevention evidence is promising but emerging. Further research in immunocompromised populations is needed.