Advanced exergy analysis is a functional approach in every aspect that can identify the irreversibility originating from internal inefficiencies of the component or the irreversibility originating from other component inefficiencies, thereby revealing the real improvement potential. This study propounds a distinctive approach because advanced exergy analysis of an integrated organic Rankine cycle (ORC)-vapor compression refrigeration (VCR) system is applied for the first time. The results show that exergy destruction of the system, which is 1.373 kW (45.58%), can be improved by considering that avoidable part of the exergy destruction can be reduced. Technical modifications to be made on components especially compressor with 0.3073 kW (83.81%) and turbine with 0.3370 kW (78.64%), lead to a considerable enhancement in the exergy performance of the system. The pump is also the most ineffective component after the mixing chamber, so it contributes less to the system performance. The technical modifications enhance the exergy efficiency of the system to 28.32% from 11.67%. The results of the sensitivity analysis indicate that the temperature differences in the condenser and boiler are the sensitivity parameters that affect the performance parameters most and least, respectively.