Downregulated GPD1 and MAGL protein levels as potential biomarkers for the metastasis of triple-negative breast tumors to axillary lymph nodes

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ŞİMŞEK T., Albayrak M. G., AKPINAR G., CANTÜRK N. Z., KASAP M.

ONCOLOGY LETTERS, cilt.27, sa.1, 2024 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 1
  • Basım Tarihi: 2024
  • Doi Numarası: 10.3892/ol.2023.14167
  • Dergi Adı: ONCOLOGY LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS
  • Anahtar Kelimeler: breast cancer, glycerol‑3‑phosphate dehydrogenase, lymph node metastasis, monoacylglycerol lipase
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Glycerol-3-phosphate dehydrogenase (GPD1) and monoacylglycerol lipase (MAGL) levels are known to be significantly downregulated in both the tissue and serum samples of patients with triple-negative breast cancer (TNBC), compared with other BC subtypes and healthy controls. As such, the association between GPD1 and MAGL levels and lymph node metastasis was evaluated in the present study. Utilizing western blotting, lymph node protein extracts from metastasized BC subtypes were analyzed and a significant downregulation of GPD1 and MAGL protein expression levels in the lymph node metastases was demonstrated in the TNBC subtype, compared with healthy controls. This finding further highlighted the potential use of these two proteins in early BC onset and metastasis detection.