Identification of miR-139-5p as a saliva biomarker for tongue squamous cell carcinoma: a pilot study

Duz M. B. , Karatas O. F. , Guzel E., Turgut N. F. , YILMAZ M. Y. , Creighton C. J. , ...More

CELLULAR ONCOLOGY, vol.39, no.2, pp.187-193, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.1007/s13402-015-0259-z
  • Title of Journal : CELLULAR ONCOLOGY
  • Page Numbers: pp.187-193
  • Keywords: Tongue squamous cell carcinoma, miRNA, Biomarker, Saliva, Microarray, TUMOR-MARKERS, MICRORNA EXPRESSION, WHOLE SALIVA, CANCER, SERUM, RNA, DIAGNOSIS, PROFILE, PLASMA

Abstract

Of all human oral carcinomas, 41 % are localized to the tongue. Despite considerable improvements in both diagnosis and treatment, tongue squamous cell carcinoma (TSCC) has remained one of the most lethal types of cancer. Here, we aimed at identifying a salivary microRNA (miRNA) expression signature specific for TSCC patients.