Role of Mesenchymal Stem Cells Transfected With Vascular Endothelial Growth Factor in Maintaining Renal Structure and Function in Rats with Unilateral Ureteral Obstruction


Ozbek E., Adaş G., Otunctemur A., Duruksu G. , Koç B., Polat E. C. , et al.

EXPERIMENTAL AND CLINICAL TRANSPLANTATION, cilt.13, ss.262-272, 2015 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 13
  • Basım Tarihi: 2015
  • Doi Numarası: 10.6002/ect.2014.0080
  • Dergi Adı: EXPERIMENTAL AND CLINICAL TRANSPLANTATION
  • Sayfa Sayısı: ss.262-272

Özet

Objectives: Mesenchymal stem cells hold promise for renal disease treatment. Vascular endothelial growth factor may heal tubule-interstitial fibrosis in unilateral ureteral obstruction by inhibiting epithelial-mesenchymal transition. We investigated the protective effect of vascular endothelial growth factor in transfected mesenchymal stem cells in unilateral ureteral obstruction-induced renal injury in rats.