Role of Mesenchymal Stem Cells Transfected With Vascular Endothelial Growth Factor in Maintaining Renal Structure and Function in Rats with Unilateral Ureteral Obstruction

Ozbek, Emin; Adaş, Gokhan; Otunctemur, Alper; Duruksu, GÖKHAN; Koç, Bora; Polat, Emre; Sarvan, Ahu; Okcu, Alparslan; Kamalı, Gulcin; Subaşı, Cansu; Karaöz, Erdal

doi:10.6002/ect.2014.0080

Role of Mesenchymal Stem Cells Transfected With Vascular Endothelial Growth Factor in Maintaining Renal Structure and Function in Rats with Unilateral Ureteral Obstruction

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Ozbek E., Adaş G., Otunctemur A., Duruksu G., Koç B., Polat E. C., ...More

EXPERIMENTAL AND CLINICAL TRANSPLANTATION, vol.13, pp.262-272, 2015 (SCI-Expanded)

Publication Type: Article / Article
Volume: 13
Publication Date: 2015
Doi Number: 10.6002/ect.2014.0080
Journal Name: EXPERIMENTAL AND CLINICAL TRANSPLANTATION
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.262-272
Keywords: Epithelial-mesenchymal transition, Renal injury, Obstructive nephropathy, Ureter obstruction, BONE-MARROW, INTERSTITIAL FIBROSIS, OXIDATIVE STRESS, STROMAL CELLS, INJURY, MODEL, VEGF, ANGIOGENESIS, KIDNEY, GLOMERULONEPHRITIS
Kocaeli University Affiliated: Yes

Abstract

Objectives: Mesenchymal stem cells hold promise for renal disease treatment. Vascular endothelial growth factor may heal tubule-interstitial fibrosis in unilateral ureteral obstruction by inhibiting epithelial-mesenchymal transition. We investigated the protective effect of vascular endothelial growth factor in transfected mesenchymal stem cells in unilateral ureteral obstruction-induced renal injury in rats.