Role of Mesenchymal Stem Cells Transfected With Vascular Endothelial Growth Factor in Maintaining Renal Structure and Function in Rats with Unilateral Ureteral Obstruction

Ozbek E., Adaş G., Otunctemur A., Duruksu G., Koç B., Polat E. C., ...More

EXPERIMENTAL AND CLINICAL TRANSPLANTATION, vol.13, pp.262-272, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13
  • Publication Date: 2015
  • Doi Number: 10.6002/ect.2014.0080
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.262-272
  • Keywords: Epithelial-mesenchymal transition, Renal injury, Obstructive nephropathy, Ureter obstruction, BONE-MARROW, INTERSTITIAL FIBROSIS, OXIDATIVE STRESS, STROMAL CELLS, INJURY, MODEL, VEGF, ANGIOGENESIS, KIDNEY, GLOMERULONEPHRITIS
  • Kocaeli University Affiliated: Yes


Objectives: Mesenchymal stem cells hold promise for renal disease treatment. Vascular endothelial growth factor may heal tubule-interstitial fibrosis in unilateral ureteral obstruction by inhibiting epithelial-mesenchymal transition. We investigated the protective effect of vascular endothelial growth factor in transfected mesenchymal stem cells in unilateral ureteral obstruction-induced renal injury in rats.