Akademik Veri Yönetim Sistemi
Diğer, ss.148-151, 2019
Myofibroblastoma of the breast is a rare mesenchymal tumor,
probably originating from stromal fibroblasts. In this case
report, cyto-histopathological findings of myofibroblastoma of
the breast are discussed.
A 68-years-old male patient was admitted to our clinic with
a rapidly growing, painless mass in the breast. Radiological
examination revealed a mobile, solid mass resembling to
fibroadenoma. Fine needle aspiration revealed spindle
cell clusters with fibrous stroma and a clear background.
Hypocellular aspirates demonstrated neoplastic cells with
cyanophilic cytoplasm and mild/moderate pleomorphism,
and naked elongated nuclei including fine granular chromatin,
nuclear groove and inclusion. The lesion was reported as
“benign spindle cell neoplasm”. Tru-cut biopsy revealed short
fascicules composed of uniform benign spindle cells with
hyalinized collagen bands accompanied by mast cells and
patchy lymphoid infiltration. Immunoreactivity was positive
with CD34, smooth muscle actin (SMA), desmin and vimentin,
but negative with CD117, CD10, Epithelial Membrane Antigen,
S-100, pan-cytokeratin and p53. This case was reported as
“classic variant of myofibroblastoma”, and the patient was
operated in another clinic. There was no recurrence during
follow-up.
Myofibroblastoma is a rare, benign mesenchymal tumor,
usually seen in the breast parenchyma. While the tumor is
diagnosed based on the fibro-myofibroblastic differentiation
characteristics, other tumors and tumor-like spindle cell
lesions should also be kept in mind. The cytological features of
22 cases in the literature were similar. Aspirates are generally
hypercellular with mild-moderate pleopmorphism, nuclear
groove and inclusions. Histopathology shows positivity for CD34,
vimentin, desmin and SMA. Clinical/radiological characteristics
and atypia, growth pattern, mitosis and immunohistochemistry
should all be evaluated together. Cytomorphology may be the
first step in diagnosis; however, immunohistochemical studies
should not be ignored in differential diagnosis.