A 5-YEAR RETROSPECTIVE ANALYSIS OF PENILE DOPPLER ULTRASOUND PARAMETERS AND BLOOD BIOMARKERS IN PATIENTS WITH ERECTILE DYSFUNCTION

Bacak A., Uluç İ., Çulha M. M.

Baltic26 11th Baltic Meeting in collaboration with the EAU, Riga, Letonya, 22 - 23 Mayıs 2026, ss.1, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Riga
  • Basıldığı Ülke: Letonya
  • Sayfa Sayıları: ss.1
  • Kocaeli Üniversitesi Adresli: Evet

Özet

A 5-year retrospective analysis of penile Doppler ultrasound parameters and blood biomarkers in patients with erectile

dysfunction

 

Introduction & Objectives

Erectile dysfunction (ED) is a multifactorial condition significantly impacting men's quality of life. Penile Doppler ultrasound (PDU) remains the gold standard for evaluating penile hemodynamics. This study aims to retrospectively evaluate the 5-year PDU results and investigate the relationship between erection hardness score (EHS), metabolic and hematological biomarkers, and penile vascular parameters including peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistive index (RI).

 

Materials & Methods

A total of 126 patients who underwent PDU for ED over the last 5 years were retrospectively analyzed. Patient data included age, body mass index (BMI), comorbidities, complete blood count including mean platelet volume (MPV), and metabolic panel including high-density lipoprotein (HDL) and triglycerides. Patients were classified based on their EHS scores (Group 1: EHS 1-2, Group 2: EHS 3-4) and vascular pathologies. Statistical comparisons were performed using multivariable logistic regression analysis, adjusting for age, BMI, and comorbidities to identify independent predictors.

 

Results

The mean age of the 126 patients was 50.7 (standard deviation 10.5) years, with a mean BMI of 27.8. Comorbidities included diabetes mellitus in 50.8%, hypertension in 56.3%, and hyperlipidemia in 35.7% of the cohort. According to PDU findings, 65.9% (83 patients) had arterial insufficiency, 34.1% (43 patients) had venous leak, and 16.7% (21 patients) had mixed vascular ED. In multivariable logistic regression analysis, Diabetes Mellitus was identified as the strongest independent risk factor for ED (OR 2.900, p < 0.010). Furthermore, serum triglyceride levels were found to be a significant risk factor for arteriogenic ED (OR 1.100, p = 0.020). Higher HDL levels were identified as an independent protective factor against arterial insufficiency (OR 0.933, 95% CI 0.890-0.977, p = 0.003). Furthermore, BMI was found to be a significant independent negative predictor for maintaining sufficient erection hardness (EHS 3-4) (OR 0.874, 95% CI 0.771-0.991, p = 0.035), regardless of age and diabetic status.

 

Conclusions

Our 5-year retrospective data reveals a strong, statistically significant relationship between lipid profiles, specifically HDL and triglycerides, and penile hemodynamics. Diabetes Mellitus and dyslipidemia appear to be independent drivers of arterial insufficiency, while an increased BMI independently reduces EHS. Comprehensive evaluation including PDU and metabolic profiling is essential for individualized ED management.