Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study

Rencber S. H., Ozbek S., Eraldemir C., Sezer Z., Kum T., Ceylan S., ...More

JOURNAL OF OVARIAN RESEARCH, vol.11, 2018 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11
  • Publication Date: 2018
  • Doi Number: 10.1186/s13048-018-0427-7
  • Journal Name: JOURNAL OF OVARIAN RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Dehydroepiandrosterone, Resveratrol, Metformin, Polycystic ovary syndrome, Oxidative stress, Inflammation, ACTIVATED PROTEIN-KINASE, THECA-INTERSTITIAL CELLS, ANTI-MULLERIAN HORMONE, OXIDATIVE STRESS, INSULIN-RESISTANCE, GRANULOSA-CELLS, FEMALE RATS, APOPTOSIS, INFLAMMATION, WOMEN
  • Kocaeli University Affiliated: Yes

Abstract

Background: PCOS is a reproductive hormonal abnormality and a metabolic disorder. It is frequently associated with insulin resistance, hyperandrogenism, chronic inflammation, and oxidative stress. We aim to investigate the potential therapeutic effects of combined therapy of resveratrol and metformin on polycystic ovaries via SIRT1 and AMPK activation.