A case of adrenal insufficiency during multisystem inflammatory syndrome in children

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KİLCİ F., Yetimakman A. F., JONES J. H., Çizmecioğlu F. M.

Clinical Pediatric Endocrinology, vol.31, no.3, pp.163-167, 2022 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.1297/cpe.2022-0011
  • Journal Name: Clinical Pediatric Endocrinology
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE
  • Page Numbers: pp.163-167
  • Keywords: adrenal insufficiency, coronavirus disease 2019 (COVID-19), cortisol
  • Kocaeli University Affiliated: Yes

Abstract

© 2022 by The Japanese Society for Pediatric Endocrinology.Multisystem inflammatory syndrome in children (MIS-C) is a disease related to coronavirus disease 2019 (COVID-19). Although the effects of COVID-19 on many systems are known, there is limited data regarding its effects on the endocrine system. This study aimed to discuss the effect of COVID-19 on cortisol dynamics in a patient who developed adrenal insufficiency after COVID-19 infection. An 11-yr-old boy with polymerase chain reaction-proven COVID-19 one month previously was referred with a five-day history of fever, vomiting, and rash. On admission, he had hypotension, tachycardia, and severe hyponatremia. After the evaluation, he was diagnosed with MIS-C and glucocorticoid therapy was initiated. During follow-up, the patient experienced adrenal insufficiency, and hydrocortisone treatment was initiated at a crisis dose. Four months later, the adrenal axis function had not recovered. The adrenocortical response in COVID-19 patients may be significantly impaired, resulting in increased mortality or morbidity.