The Role of beta-Catenin in Bcr/Abl Negative Myeloproliferative Neoplasms: An Immunohistochemical Study


GEDÜK A., Atesoglu E. B. , TARKUN P. , MEHTAP Ö. , Hacihanefioglu A. , Demirsoy E. T. , et al.

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, cilt.15, ss.785-789, 2015 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 15 Konu: 12
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.clml.2015.08.084
  • Dergi Adı: CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
  • Sayfa Sayısı: ss.785-789

Özet

The dysregulation of the Wnt/beta-catenin signaling pathway causes various diseases. In this study we aimed to reveal the role of beta-catenin in bcr/abl-negative myeloproliferative neoplasms. The expression of beta-catenin was examined in bone marrow with immunohistochemical method in 66 patients and in 30 control participants. The results suggest that beta-catenin has a role in the angiogenesis of primary myelofibrosis and in the thrombopoiesis of policythemia vera and essential thrombocytemia.