The Role of beta-Catenin in Bcr/Abl Negative Myeloproliferative Neoplasms: An Immunohistochemical Study

GEDÜK A., Atesoglu E. B., TARKUN P., MEHTAP Ö., Hacihanefioglu A., Demirsoy E. T., ...Daha Fazla

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, cilt.15, sa.12, ss.785-789, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 12
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.clml.2015.08.084
  • Dergi Adı: CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.785-789
  • Anahtar Kelimeler: Angiogenesis, Essential thrombocytemia, Primary myelofibrosis, Thrombopoiesis, Wnt/beta-catenin signaling pathway, ACUTE MYELOID-LEUKEMIA, PATHWAY, MODULATION, CELLS, PROLIFERATION, ANGIOGENESIS, EXPRESSION, DISORDERS, THERAPY, CANCER
  • Kocaeli Üniversitesi Adresli: Evet

Özet

The dysregulation of the Wnt/beta-catenin signaling pathway causes various diseases. In this study we aimed to reveal the role of beta-catenin in bcr/abl-negative myeloproliferative neoplasms. The expression of beta-catenin was examined in bone marrow with immunohistochemical method in 66 patients and in 30 control participants. The results suggest that beta-catenin has a role in the angiogenesis of primary myelofibrosis and in the thrombopoiesis of policythemia vera and essential thrombocytemia.