The Role of beta-Catenin in Bcr/Abl Negative Myeloproliferative Neoplasms: An Immunohistochemical Study


GEDÜK A. , Atesoglu E. B. , TARKUN P. , MEHTAP Ö. , Hacihanefioglu A. , Demirsoy E. T. , ...More

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, vol.15, no.12, pp.785-789, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 12
  • Publication Date: 2015
  • Doi Number: 10.1016/j.clml.2015.08.084
  • Title of Journal : CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
  • Page Numbers: pp.785-789

Abstract

The dysregulation of the Wnt/beta-catenin signaling pathway causes various diseases. In this study we aimed to reveal the role of beta-catenin in bcr/abl-negative myeloproliferative neoplasms. The expression of beta-catenin was examined in bone marrow with immunohistochemical method in 66 patients and in 30 control participants. The results suggest that beta-catenin has a role in the angiogenesis of primary myelofibrosis and in the thrombopoiesis of policythemia vera and essential thrombocytemia.