Akademik Veri Yönetim Sistemi
INTERNATIONAL ANKARA CONGRESS ON SCIENTIFIC RESEARCH VI, Ankara, Türkiye, 1 - 03 Nisan 2022, ss.84-91
Thymomas are rare tumors, but among the mediastinal neoplasms, they are one of the most common tumors in adults. They vary histologically, biologically and genetically. The
morphological spectrum is quite large, and tumors with more than one histological pattern are
more common than pure histological subtypes. The focus of the new World Health
Organization thymoma classification is to describe the histopathological features of thymoma
and diagnostic immunohistochemical profiles, improving diagnostic reproducibility.
In this study, we aimed to reveal the tumor subtypes, the incidence of subtypes and our 15-
year clinicopathological experience of patients diagnosed with thymoma after excisional
biopsy of their anterior mediastinal mass.
In this study, 65 cases who underwent biopsy/excisional biopsy for thymic neoplasia in our
department between January 2006 and December 2021 were retrospectively analyzed. Age,
gender, tru-cut biopsy / excisional resection type and histopathological diagnosis of all cases
were recorded.
Only tru-cut biopsy was available in 21 of 65 patients with pre-diagnosis of thymic neoplasia.
One patient was diagnosed with thymic hyperplasia. And these cases were excluded from the
study. There were 43 patients who underwent resection with the diagnosis of thymoma and
were included in the study. Their age ranged from 26-84. The mean age was 57.5 years and
26 of these cases were male and 17 were female. Of these patients, 32.5% Type B1, 30.2%
Type B2, 18.6% Type AB, 14.0% Type A thymoma, 2.3% metaplastic thymoma, 2% 0.3 of
them were reported as micronodular thymoma.
Thymic lesions are the most common group of mediastinal tumors seen in adults, and
thymomas are the most common among them. They are usually seen as an asymptomatic
mass between the ages of 40-50, with equal frequency in men and women. And thymomas
are defined as anterior mediastinal neoplasms formed by thymic epithelial cells and
lymphocytes together. Although they are mostly encapsulated, well-differentiated tumors,
local invasion, pleural spread and extrathoracic metastases can also be seen. Subtyping in
thymomas is very important in terms of patient management and histopathological
examination after excision of the entire mass is the gold standard method.