This study is part of a research program that is being carried out as a NATO Project 977231 "Seismic Assessment and Rehabilitation of Existing Buildings", led by Middle East Technical University. Within the framework of the research program a new seismic retrofitting methodology is experimentally under investigation. The behavior of hollow brick infilled reinforced concrete frames strengthened by Carbon Fiber Reinforced Polymers (CFRP) has been studied. The main deficiencies of the one-third scale one-bay, two-story test frames were insufficient column lap splice length, poor confinement, and inadequate anchorage length of beam bottom reinforcement. In all specimens beams were stronger than columns and no joint shear reinforcement was used.