Predictive value of lymphocyte-to-monocyte ratio in patients with contrast-induced nephropathy after percutaneous coronary intervention for acute coronary syndrome

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KARAÜZÜM İ., KARAÜZÜM K., AÇAR B., HANCI K., Bildirici H. I. U., KILIÇ T., ...More

JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE, vol.9, no.2, pp.123-130, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.2478/jtim-2021-0024
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.123-130
  • Keywords: lymphocyte-to-monocyte ratio, acute coronary syndrome, contrast-induced nephropathy, percutaneous coronary intervention, ACUTE KIDNEY INJURY, ELEVATION MYOCARDIAL-INFARCTION, TERM OUTCOMES, RISK-FACTORS, ASSOCIATION, NEUTROPHIL, PLATELET, DYSFUNCTION, UNDERWENT, SEVERITY
  • Kocaeli University Affiliated: Yes


Background and Objectives: Lymphocyte-to-monocyte ratio (LMR) has emerged as a new indirect marker of inflammation, which is associated with adverse outcomes in cardiovascular diseases. The aim of this study was to evaluate whether admission LMR is associated with contrast-induced nephropathy (CIN) in patients who underwent percutaneous coronary intervention for acute coronary syndrome (ACS). Methods: A total of 873 patients were assessed. LMR was calculated via dividing lymphocyte count by monocyte count. Results: LMR was significantly lower in the with-CIN group. ROC analysis showed that the LMR ratios <2.52 predicted CIN development with sensitivity of 66.3% and specificity of 55.8%. Multivariate analysis showed that eGFR, admission glucose, and LMR were independent predictors of CIN in patients with ACS. Conclusion: LMR is an easily accessible marker and could be used as a predictor of CIN in patients with ACS undergoing percutaneous coronary intervention.