Predictive value of lymphocyte-to-monocyte ratio in patients with contrast-induced nephropathy after percutaneous coronary intervention for acute coronary syndrome

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KARAÜZÜM İ., KARAÜZÜM K., AÇAR B., HANCI K., Bildirici H. I. U., KILIÇ T., ...Daha Fazla

JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE, cilt.9, sa.2, ss.123-130, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.2478/jtim-2021-0024
  • Dergi Adı: JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.123-130
  • Anahtar Kelimeler: lymphocyte-to-monocyte ratio, acute coronary syndrome, contrast-induced nephropathy, percutaneous coronary intervention, ACUTE KIDNEY INJURY, ELEVATION MYOCARDIAL-INFARCTION, TERM OUTCOMES, RISK-FACTORS, ASSOCIATION, NEUTROPHIL, PLATELET, DYSFUNCTION, UNDERWENT, SEVERITY
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Background and Objectives: Lymphocyte-to-monocyte ratio (LMR) has emerged as a new indirect marker of inflammation, which is associated with adverse outcomes in cardiovascular diseases. The aim of this study was to evaluate whether admission LMR is associated with contrast-induced nephropathy (CIN) in patients who underwent percutaneous coronary intervention for acute coronary syndrome (ACS). Methods: A total of 873 patients were assessed. LMR was calculated via dividing lymphocyte count by monocyte count. Results: LMR was significantly lower in the with-CIN group. ROC analysis showed that the LMR ratios <2.52 predicted CIN development with sensitivity of 66.3% and specificity of 55.8%. Multivariate analysis showed that eGFR, admission glucose, and LMR were independent predictors of CIN in patients with ACS. Conclusion: LMR is an easily accessible marker and could be used as a predictor of CIN in patients with ACS undergoing percutaneous coronary intervention.