Electro-osmotic flow-based microfluidic biosensor: effect of design and operating parameters

Soni S., Yadav A., Samir S., ARICI M.

Microsystem Technologies, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1007/s00542-024-05823-8
  • Dergi Adı: Microsystem Technologies
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Applied Science & Technology Source, Compendex, Computer & Applied Sciences, INSPEC
  • Kocaeli Üniversitesi Adresli: Evet

Özet

AC electrokinetics have been used to enhance the performance of slow diffusion-based microfluidic biosensors. Electro-osmotic flow generated by non-uniform wall surface charge overcomes this problem by producing re-circulatory flow near the sensor surface. Using such flow patterns, a two-dimensional computational model was developed and investigated for binding enhancement strategies. The effect of various design and operating parameters was studied. The parameters like concentrations of antigen, bulk flow velocity, zeta potential, reaction surface length, pitch, electrode voltage, channel geometry, length of electrode, and initial position of electrode showed a significant improvement of 360.20%, 205.23%, 84.82%, 48.93%, 28.53%, 26.97%, 17.58%, 6.80%, and 4.43%, respectively, on biosensors binding performance for the initial period of 100 s.