Amyloidosis is a group disease that is characterized by deposited proteins in the skin and other organs. It is classified as cutaneous amyloidosis, systemic amyloidosis and heredofamilial amyloidosis. Purpuric lesions and ecchymoses are the most common skin findings in systemic amyloidosis. However, glossitis, macroglossia, bullous lesions, alopecia and cutis verticis gyrata may be seen. In patient with primer systemic amyloidosis, acquired hemostatic abnormalities, hyperfibrinolysis, coagulation factor deficiencies, platelet dysfunction and increased fragility of blood vessels can be regarded as the most important pathogenetic factors. The mechanism of the localised bleeding is not completely understood. Here, we presented a patient with renal amyloidosis and periorbital ecchymoses in order to emphasize the necessity for remembering systemic amyloidosis in the differential diagnoses of periorbital ecchymoses.