Metoclopramide induced parkinsonism and mixed polyneuropathy in a patient with acute renal failure: A case report

Bayulkem K., Karabas G., Erkal B., Yilmaz A.

7th Congress of the European-Society-of-Clinical-Neuropharmacology, Trieste, Italy, 5 - 09 May 2004, pp.219-226 identifier

  • Publication Type: Conference Paper / Full Text
  • Volume:
  • City: Trieste
  • Country: Italy
  • Page Numbers: pp.219-226
  • Kocaeli University Affiliated: No


39 years of age, a pregnancy woman in 40, gestastional week; following subtotal hysterectomy applying for uterus rupture occuring while is followed with diagnosis of preeclampsia had have been hypo-volemic shock. Although laparatomy and medical therapy have been applied, her anurea has not been improved. Patient has been pursued with diagnosis of Hellp syndrome. Occuring symptoms were found consist with Parkinsonism during haemodialysis applied for acute renal failure (ARF) developing, in the 7th days of 30 mg IV metoclopramide per day added to treatment for nausea. These symptoms disappeared within ten days after only metoclopramide with drawal without anti-parkinson medicine. But she were not walking, in the repeated neurological examination, mixed polyneuropathy consist with EMG findings were detected. It is possible seen to say that metoclopramide in patients with ARF is necessity of using in decrease doses carefully, and acute mixt type polineuropathy due to ureamia in the same patients could sometimes accompany to metoclopramide induced parkinsonism.