Atıf İçin Kopyala
Thalmann G., Sikes R., Wu T., Degeorges A., Chang S., Ozen M., ...Daha Fazla
PROSTATE, cilt.44, sa.2, ss.91-103, 2000 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
44
Sayı:
2
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Basım Tarihi:
2000
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Dergi Adı:
PROSTATE
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Sayfa Sayıları:
ss.91-103
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Anahtar Kelimeler:
prostate cancer progression, androgen-independence, stromal-epithelial interaction, skeletal metastasis, PSA expression, cytogenetics, CGH, chromosomal losses and gains, ORTHOTOPIC IMPLANTATION, TRANSGENIC MOUSE, BONE FIBROBLASTS, GROWTH-INVIVO, TUMOR-GROWTH, ATHYMIC MICE, NEU ONCOGENE, NUDE-MICE, CARCINOMA, HORMONE
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Kocaeli Üniversitesi Adresli:
Evet
Özet
BACKGROUND. Clinically, the lethal phenotypes of human prostate cancer are characterized by their progression to androgen-independence and their propensity to form osseous metastases. We reported previously on the establishment of androgen-independent (AI) human prostate cancer cell lines derived from androgen-dependent (AD) LNCaP cells, with androgen independence defined as the capability of prostate cancer cells to grow in castrated hosts. One of the sublines, C4-2, was found to be AI, highly tumorigenic, and metastatic, having a proclivity for metastasis to the bone.