LNCaP progression model of human prostate cancer: Androgen-independence and osseous metastasis

Thalmann G., Sikes R., Wu T., Degeorges A., Chang S., Ozen M. , ...More

PROSTATE, vol.44, no.2, pp.91-103, 2000 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 2
  • Publication Date: 2000
  • Title of Journal : PROSTATE
  • Page Numbers: pp.91-103
  • Keywords: prostate cancer progression, androgen-independence, stromal-epithelial interaction, skeletal metastasis, PSA expression, cytogenetics, CGH, chromosomal losses and gains, ORTHOTOPIC IMPLANTATION, TRANSGENIC MOUSE, BONE FIBROBLASTS, GROWTH-INVIVO, TUMOR-GROWTH, ATHYMIC MICE, NEU ONCOGENE, NUDE-MICE, CARCINOMA, HORMONE


BACKGROUND. Clinically, the lethal phenotypes of human prostate cancer are characterized by their progression to androgen-independence and their propensity to form osseous metastases. We reported previously on the establishment of androgen-independent (AI) human prostate cancer cell lines derived from androgen-dependent (AD) LNCaP cells, with androgen independence defined as the capability of prostate cancer cells to grow in castrated hosts. One of the sublines, C4-2, was found to be AI, highly tumorigenic, and metastatic, having a proclivity for metastasis to the bone.