EVALUATION OF THE LEVELS AND ETHIOLOGIC ROLES OF HEPCIDIN AND IRON METABOLISM IN PRE-DIABETIC PATIENTS


Yildirim A., Musul M. M. , Yalcinkaya E., TARKUN İ.

ACTA MEDICA MEDITERRANEA, vol.37, no.1, pp.743-748, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.19193/0393-6384_2021_1_114
  • Title of Journal : ACTA MEDICA MEDITERRANEA
  • Page Numbers: pp.743-748

Abstract

Objective: Iron can increase the development of type 2 Diabetes Mellitus (DM) through the formation of reactive oxygen radicals and subsequent oxidative distress. Hepcidin is a hormone that regulates iron absorption and distribution to tissues. Both hepcidin and ferritin are acute phase reactants and their serum levels may increase with all kinds of inflammations. Proinflammatory cytokines are known to increase in type 2 DM. For these reasons, we aimed to investigate the role of serum hepcidin and iron markers in the etiology of diabetes in pre-diabetic patients.