EVALUATION OF THE LEVELS AND ETHIOLOGIC ROLES OF HEPCIDIN AND IRON METABOLISM IN PRE-DIABETIC PATIENTS

Yildirim A., Musul M. M., Yalcinkaya E., TARKUN İ.

ACTA MEDICA MEDITERRANEA, cilt.37, sa.1, ss.743-748, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.19193/0393-6384_2021_1_114
  • Dergi Adı: ACTA MEDICA MEDITERRANEA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Sayfa Sayıları: ss.743-748
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Objective: Iron can increase the development of type 2 Diabetes Mellitus (DM) through the formation of reactive oxygen radicals and subsequent oxidative distress. Hepcidin is a hormone that regulates iron absorption and distribution to tissues. Both hepcidin and ferritin are acute phase reactants and their serum levels may increase with all kinds of inflammations. Proinflammatory cytokines are known to increase in type 2 DM. For these reasons, we aimed to investigate the role of serum hepcidin and iron markers in the etiology of diabetes in pre-diabetic patients.