EVALUATION OF THE LEVELS AND ETHIOLOGIC ROLES OF HEPCIDIN AND IRON METABOLISM IN PRE-DIABETIC PATIENTS

Yildirim A., Musul M. M., Yalcinkaya E., TARKUN İ.

ACTA MEDICA MEDITERRANEA, vol.37, no.1, pp.743-748, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.19193/0393-6384_2021_1_114
  • Journal Name: ACTA MEDICA MEDITERRANEA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Page Numbers: pp.743-748
  • Kocaeli University Affiliated: Yes

Abstract

Objective: Iron can increase the development of type 2 Diabetes Mellitus (DM) through the formation of reactive oxygen radicals and subsequent oxidative distress. Hepcidin is a hormone that regulates iron absorption and distribution to tissues. Both hepcidin and ferritin are acute phase reactants and their serum levels may increase with all kinds of inflammations. Proinflammatory cytokines are known to increase in type 2 DM. For these reasons, we aimed to investigate the role of serum hepcidin and iron markers in the etiology of diabetes in pre-diabetic patients.