Genomic copy number alteration of glycolytic pathway in endometrial cancer


Yilmaz M., Akkoyunlu D. , Keskin S. , DOĞER E. , ÇİNE N. , SAVLI H.

EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, cilt.40, ss.640-646, 2019 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 40 Konu: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.12892/ejgo4765.2019
  • Dergi Adı: EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
  • Sayfa Sayıları: ss.640-646

Özet

Metabolic reprogramming is one of the hallmarks of cancer cells, but very little is known about the difference in the expression of metabolic genes between cancer and normal tissues. The degree to which different cancer types display similar metabolic alteration is poorly understood. The best-known example of metabolic disturbance in cancer cells is the Warburg effect. The Warburg effect is the phenomenon of the cancer cells favoring the anaerobic glycolysis even in the presence of oxygen. It is displayed by most cancer cells. Although the genomic, transcriptomic, and proteomic studies have been published, metalobomic differences are still a major gap in our knowledge. Among women the most common malignancy is endometrial cancer. In this retrospective study, the authors investigated the genomic instability of glycolytic genes in endometrial carcinoma patients using array-based comparative genomic hybridization (aCGH) reports. The results indicate that among 54 patients diagnosed with endometrial carcinoma, in 21 patients, pathogenic genomic instability was detected which are linked with the disease. Among the 21 patients who had genomic instability, 19 of them (90.5%) displayed copy number variations of at least one or more glycolysis genes based on the genomic laboratory reports of the patients.