Carotid artery velocity-time integral as a surrogate for left ventricular outflow tract velocity-time integral during fluid resuscitation in the emergency department


Korkan Ü., PEKDEMİR M., ÖZTURAN İ. U., DOĞAN N. Ö., YAKA E., YILMAZ S.

American Journal of Emergency Medicine, cilt.108, ss.64-71, 2026 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 108
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1016/j.ajem.2026.06.011
  • Dergi Adı: American Journal of Emergency Medicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, Health Research Premium Collection (ProQuest)
  • Sayfa Sayıları: ss.64-71
  • Anahtar Kelimeler: Blood volume determinations (MeSH database), Carotid artery ultrasonography, Echocardiography, Stroke volumes
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Background: Accurate stroke volume assessment is essential for guiding fluid resuscitation in critically ill patients. Although left ventricular outflow tract velocity-time integral (LVOT-VTI) is widely used, its acquisition is often challenging in the ED, whereas the easier-to-measure common carotid artery velocity-time integral (CCA-VTI) has limited supporting evidence in heterogeneous ED populations. This study aimed to evaluate the correlation and agreement between CCA-VTI and LVOT-VTI in critically ill ED patients undergoing fluid resuscitation. Methods: This prospective cross-sectional study was conducted in a tertiary-care ED between May and September 2025. Adult patients with critical illness and indications for intravenous fluid resuscitation were enrolled. Bedside ultrasound measurements of LVOT-VTI and CCA-VTI were obtained before and after fluid administration. Correlation was assessed using Spearman's coefficient, and agreement was evaluated using Bland–Altman analysis. Results: Fifty patients were included. LVOT-VTI and CCA-VTI showed strong correlation before fluid resuscitation (r = 0.88; p < 0.001), which increased after resuscitation (r = 0.92; p < 0.001). Among fluid responders (n = 24), correlation increased from r = 0.62 to r = 0.94. Percentage (Δ) changes in CCA-VTI were strongly correlated with LVOT-VTI (r = 0.74, p < 0.001). Bland–Altman analysis demonstrated good agreement between CCA-VTI and LVOT-VTI, with a mean bias of 0.12 cm before resuscitation (95% limits of agreement [LoA], −2.07 to 2.32 cm) and 0.08 cm after resuscitation (95% LoA, −1.26 to 1.41 cm). Conclusion: CCA-VTI demonstrated strong correlation and acceptable agreement with LVOT-VTI in critically ill ED patients and may serve as a practical bedside adjunct when LVOT imaging is challenging.