The effects of somatostatin on the microperfusion of the pancreas during acute necrotizing pancreatitis in rats

Piri M., Alhan E., Kucuktulu U., Ercin C., Deger O., Yucel K., ...More

HEPATO-GASTROENTEROLOGY, vol.49, no.45, pp.833-837, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 45
  • Publication Date: 2002
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.833-837
  • Kocaeli University Affiliated: No


Background/Aims: Autodigestion and impairment of microcirculation of the pancreas play an important role in the pathogenesis of acute pancreatitis. Somatostatin with the reducing effect on the hepatosplachnic blood flow decreases exocrine pancreatic secretion. Microcirculatory changes are central to the pathogenesis of acute pancreatitis. However, little is known about the effects of somatostatin on the pancreatic tissue oxygen pressure and acinar cell injury during acute pancreatitis.