Akademik Veri Yönetim Sistemi
International Mediterranean Science and Engineering Congress (IMSEC 2018), Adana, Türkiye, 24 - 26 Ekim 2018, ss.483
Magnetic tweezers are able to manipulate cells or biomolecules for various applications and measurements. In this work, a horizontal magnetic tweezer is designed, modeled and controlled for single molecule manipulations. Micron sized superparamagnetic particles are manipulated by the horizontal magnetic tweezers, because these microparticles can be functionalized with receptors in order to capture the target biomolecules, and the loaded magnetic particles can be moved to a certain place by using an external magnetic field. Dynamic modeling of the system is obtained by using magnetic monopole and magnetic circuit approaches. An offset current based feedback linearizing controller is designed to ensure a wide range of operation conditions with zero steadystate error. A particle detection and tracking algorithm is developed for using with visual measurement system. Numerical simulations and experiments are then performed to validate the derived model and control system. The control performance is evaluated with experiments in order to demonstrate the effectiveness and feasibility of the designs. It is showed that the fully controlled horizontal magnetic tweezer is able to yield a wide range of piconewton scale forces on a superparamagnetic microparticle to provide nano-stepping and long-range positioning of the particle. The designed magnetic tweezer can exert forces over 24 pN to control a magnetic bead of 1 to 10 micrometer of diameter with less than 1 A current requirement. The developed system can be used for single cell/molecule separation, and biosensor developments.