Acid Dissociation Constants of Some Novel Isatin Thiosemicarbazone Derivatives

Ozkutuk M., ÖĞRETİR C., ARSLAN T., Kandemirli F., Koksoy B.

JOURNAL OF CHEMICAL AND ENGINEERING DATA, vol.55, no.8, pp.2714-2718, 2010 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 8
  • Publication Date: 2010
  • Doi Number: 10.1021/je9009738
  • Journal Name: JOURNAL OF CHEMICAL AND ENGINEERING DATA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2714-2718
  • Kocaeli University Affiliated: Yes

Abstract

The acid dissociation constants (pK(a)) of five novel biologically active isatin thiosemicarbazone derivatives were determined by a UV-visible spectrophotometric technique at (25 +/- 0.1) degrees C. The deprotonations for all studied molecules were found to occur at the substituted fa-amino group, whereas the protonation seems to take place at the oxo group of the five-membered ring.