Acid Dissociation Constants of Some Novel Isatin Thiosemicarbazone Derivatives
JOURNAL OF CHEMICAL AND ENGINEERING DATA, vol.55, no.8, pp.2714-2718, 2010 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 55 Issue: 8
- Publication Date: 2010
- Doi Number: 10.1021/je9009738
- Journal Name: JOURNAL OF CHEMICAL AND ENGINEERING DATA
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.2714-2718
- Kocaeli University Affiliated: Yes
Abstract
The acid dissociation constants (pK(a)) of five novel biologically active isatin thiosemicarbazone derivatives were determined by a UV-visible spectrophotometric technique at (25 +/- 0.1) degrees C. The deprotonations for all studied molecules were found to occur at the substituted fa-amino group, whereas the protonation seems to take place at the oxo group of the five-membered ring.