Characterization of cancer stem-like cells in chordoma Laboratory investigation

Aydemir E., Bayrak O. F., Sahin F., Atalay B., Kose G. T., Ozen M., ...Daha Fazla

JOURNAL OF NEUROSURGERY, cilt.116, sa.4, ss.810-820, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 116 Sayı: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.3171/2011.12.jns11430
  • Dergi Adı: JOURNAL OF NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.810-820
  • Anahtar Kelimeler: chordoma, cancer stem-like cell, differentiation, retinoic acid, SSEA-1, nucleus pulposus, oncology, SKULL BASE CHORDOMAS, TERM-FOLLOW-UP, RETINOIC ACID, PROSPECTIVE IDENTIFICATION, PROGENITOR CELLS, IN-VITRO, DIFFERENTIATION, MANAGEMENT, MARKER, GROWTH
  • Kocaeli Üniversitesi Adresli: Hayır

Özet

Object. Chordomas are locally aggressive bone tumors known to arise from the remnants of the notochord. Because chordomas are rare, molecular studies aimed at developing new therapies are scarce and new approaches are needed. Chordoma cells and cancer stem-like cells share similar characteristics, including self-renewal, differentiation, and resistance to chemotherapy. Therefore, it seems possible that chordomas might contain a subpopulation of cancer stem-like cells. The aim of this study is to determine whether cancer stem-like cells might be present in chordomas.