A major advantage of ultrasound (US) has been reduction in the amount of local anaesthetic (LA) needed for successful blocks. Reduced LA requirement reduces the risk of LA toxicity when multiple blocks are to be done for surgery of more than one extremity in the same patient. The 38-year-old female was scheduled for elective surgery of polydactilia in her right foot and syndactili in her right hand. A sciatic nerve block and an infraclavicular block were applied to the patient, with ultrasound guidance. The sciatic block was performed at the popliteal level in figure of four position in prone position. The lateral sagital technique was used for the infraclavicular block. Both blocks were successful, and the patient was ready for surgery 30 minutes after block performances. The patient didn't need any additional anaesthetic or analgesic during the operation. Surgery was performed uneventfully on both extremities. This is the first case report in the literature in which multiple blocks were applied to two different extremities, the leg and arm. In conclusion, our case report is a good example of multiple blocks in different extremities being performed successfully and safely according to US guidance and using low doses of local anaesthetics.