The theoretical cross section calculations for the astrophysical p process are very crucial due to the most of the related reactions are technically vet difficult to measure at the laboratory. On the other hand, the theoretical cross sections are not in agreement with the experimental results, especially for the (alpha,gamma) reactions. One of the main reason of the difference between theoretical and experimental cross section is description of the alpha+nucleus optical model potential. In order to understand current situation and improvement of the theoretical calculations, the Sn-112(alpha,gamma)Te-116 reaction were investigated for different global optical model potentials at the astrophysically interested energies. Astrophysical S factors were also calculated and compared with experimental data available at EXFOR database.