The stereochemistry of the 1,2-addition of Grignard reagents to some steroidal unsaturated ketones

Uyanik C., Hanson J., Hitchcock P.

JOURNAL OF CHEMICAL RESEARCH, no.8, pp.474-476, 2003 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: Issue: 8
  • Publication Date: 2003
  • Journal Name: JOURNAL OF CHEMICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Metadex
  • Page Numbers: pp.474-476
  • Kocaeli University Affiliated: Yes

Abstract

The stereochemistry of 3beta,17beta-dihydroxy-3alpha-ethylandrost-4-ene, 3alpha,17beta-dihydroxy-3beta-methylestr-4-ene and 3beta-acetoxy-7alpha,17beta-dihydroxy-7beta-methylandrost-5-ene, which were obtained by Grignard reactions from the corresponding alphabeta-unsaturated ketones, have been established by X-ray crystallography.