Agmatine, A Metabolite of Arginine, Improves Learning and Memory in Streptozotocin-Induced Alzheimer's Disease Model in Rats

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Sirvanci-Yalabik M., Sehirli A. O., Utkan T., Arıcıoğlu F.

KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY, vol.26, pp.342-354, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 26
  • Publication Date: 2016
  • Doi Number: 10.5455/bcp.20161121125642
  • Journal Name: KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.342-354
  • Keywords: agmatine, streptozotocine, Alzheimer's disease, passive avoidance, Morris water maze, PREFRONTAL CORTICAL MORPHOLOGY, NITRIC-OXIDE SYNTHASE, OXIDATIVE STRESS, ENDOGENOUS AGMATINE, CEREBRAL-ISCHEMIA, HIPPOCAMPAL, PROTECTS, BRAIN, GLUTAMATE, NMDA
  • Kocaeli University Affiliated: Yes

Abstract

Objective: Agmatine, the decarboxylation product of arginine produced by arginine decarboxylase, is a novel neurotransmitter and exists in the mammalian brain. Agmatine has been reported to modulate cognitive functions, including learning and memory.