Agmatine, A Metabolite of Arginine, Improves Learning and Memory in Streptozotocin-Induced Alzheimer's Disease Model in Rats

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Sirvanci-Yalabik M., Sehirli A. O., Utkan T., Arıcıoğlu F.

KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY, cilt.26, ss.342-354, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5455/bcp.20161121125642
  • Dergi Adı: KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.342-354
  • Anahtar Kelimeler: agmatine, streptozotocine, Alzheimer's disease, passive avoidance, Morris water maze, PREFRONTAL CORTICAL MORPHOLOGY, NITRIC-OXIDE SYNTHASE, OXIDATIVE STRESS, ENDOGENOUS AGMATINE, CEREBRAL-ISCHEMIA, HIPPOCAMPAL, PROTECTS, BRAIN, GLUTAMATE, NMDA
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Objective: Agmatine, the decarboxylation product of arginine produced by arginine decarboxylase, is a novel neurotransmitter and exists in the mammalian brain. Agmatine has been reported to modulate cognitive functions, including learning and memory.