The Use of Cangrelor as Bridge Antiplatelet Therapy in a Patient with Recent Percutaneous Coronary Intervention for Acute Coronary Syndrome, Who Developed Esophageal Perforation After Transesophageal Echocardiography Yakın Zamanda Akut Koroner Sendrom Nedeniyle Perkütan Koroner Girişim Öyküsü Olan ve Transözofageal Ekokardiyografi Sonrasında Özofagus Perforasyonu Gelişen Bir Hastada Kangrelorun Köprü Antitrombosit Tedavisi Olarak Kullanılması

GULIYEVA U., KARAÜZÜM K., ÇAM İ., Israfilov R., KOÇ A. F., MIRZAMIDINOV D., ...Daha Fazla

Turk Kardiyoloji Dernegi Arsivi, cilt.52, sa.5, ss.352-356, 2024 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 5
  • Basım Tarihi: 2024
  • Doi Numarası: 10.5543/tkda.2023.50000
  • Dergi Adı: Turk Kardiyoloji Dernegi Arsivi
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Central & Eastern European Academic Source (CEEAS), Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.352-356
  • Anahtar Kelimeler: Antiplatelet, cangrelor, esophageal perforation, transesophageal echocardiography
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Dual antiplatelet therapy (DAPT) is a vital part of the pharmacological management in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). While early discontinuation of DAPT increases ischemic risk, some patients on DAPT may require urgent surgery, necessitating its interruption. Cangrelor, an intravenous P2Y12 antagonist, provides strong platelet inhibition within minutes and platelet activity normalizes within one hour after the cessation of the drug. Bridging antiplatelet therapy with cangrelor has been increasingly studied as an alternative option to ensure the continuation of platelet inhibition in CAD patients who require discontinuation of DAPT. The present patient, with a recent history of PCI for acute coronary syndrome, experienced a significant esophageal perforation following transesophageal echocardiography (TEE). This severe complication was effectively managed endoscopically, and as part of the recent PCI treatment, prolonged cangrelor infusion was successfully utilized with no thrombotic or bleeding events throughout the management of the complication.