The Short- and Long-term Effects of Estrogen Deficiency on Apoptosis in Musculoskeletal Tissues: An Experimental Animal Model Study

Aydın A., Kenar H., Atmaca H., Alıcı T., Gacar G., Müezzinoğlu Ü. S., ...More

ARCHIVES OF IRANIAN MEDICINE, vol.16, no.5, pp.271-276, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 5
  • Publication Date: 2013
  • Journal Name: ARCHIVES OF IRANIAN MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.271-276
  • Keywords: Apoptosis, estrogen, estrogen deficiency, osteoporosis, OSTEOCYTE APOPTOSIS, SKELETAL-MUSCLE, RECEPTOR-ALPHA, MESSENGER-RNA, EXPRESSION, TENDON, BCL-2, FATIGUE, SIGNALS, CELLS
  • Kocaeli University Affiliated: Yes

Abstract

Background: Estrogen is the major sex steraid affecting the growth, remodeling, and homeostasis Of the-female skeleton. Estrogen loss in postmenopausal women leads to osteoporosis. The aim of this study was to evaluate the early and long- term effects of estrogen loss on bones, tendons, Muscles, and menisci in ovariectomized rats.