The Evaluation of Human Tenon's Fibroblasts and Endothelial Cell Responses to Antifibrotics Alone and in Combination with alpha-Tocopherol

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Engin K. N., Erdem-Kuruca S., Akgun-Dar K., Cetin B., Karadenizli S., Gurel E., ...More

CURRENT EYE RESEARCH, vol.40, no.1, pp.19-29, 2015 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 40 Issue: 1
• Publication Date: 2015
• Doi Number: 10.3109/02713683.2014.909496
• Journal Name: CURRENT EYE RESEARCH
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.19-29
• Keywords: alpha-tocopherol, 5-fluorouracil, antifibrotic, apoptosis, endothelium, glaucoma surgery, Tenon's fibroblast, mitomycin, GLAUCOMA FILTRATION SURGERY, MITOMYCIN-C, IN-VITRO, VITAMIN-E, INHIBITS PROLIFERATION, CORNEAL ENDOTHELIUM, CAPSULE FIBROBLASTS, EXPERIMENTAL-MODEL, FILTERING SURGERY, CYCLOSPORINE-A
• Kocaeli University Affiliated: Yes

Abstract

Purpose: We aimed to evaluate the influence of current antifibrotic agents as well as the possible results obtained by combining these agents. This study included alpha-tocopherol, a strong antifibrotic and an efficient neuromediator of pathways used by other agents.