The Evaluation of Human Tenon's Fibroblasts and Endothelial Cell Responses to Antifibrotics Alone and in Combination with alpha-Tocopherol

Engin K. N., Erdem-Kuruca S., Akgun-Dar K., Cetin B., Karadenizli S., Gurel E., ...More

CURRENT EYE RESEARCH, vol.40, no.1, pp.19-29, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.3109/02713683.2014.909496
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.19-29
  • Keywords: alpha-tocopherol, 5-fluorouracil, antifibrotic, apoptosis, endothelium, glaucoma surgery, Tenon's fibroblast, mitomycin, GLAUCOMA FILTRATION SURGERY, MITOMYCIN-C, IN-VITRO, VITAMIN-E, INHIBITS PROLIFERATION, CORNEAL ENDOTHELIUM, CAPSULE FIBROBLASTS, EXPERIMENTAL-MODEL, FILTERING SURGERY, CYCLOSPORINE-A
  • Kocaeli University Affiliated: Yes


Purpose: We aimed to evaluate the influence of current antifibrotic agents as well as the possible results obtained by combining these agents. This study included alpha-tocopherol, a strong antifibrotic and an efficient neuromediator of pathways used by other agents.