Antiviral drug-associated potential vaccine-escape hepatitis B virus mutants in Turkish patients with chronic hepatitis B

Sayan, M.; Akhan, S.

doi:10.1016/j.ijid.2011.05.019

Antiviral drug-associated potential vaccine-escape hepatitis B virus mutants in Turkish patients with chronic hepatitis B

Atıf İçin Kopyala

Sayan M., Akhan S. C.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, cilt.15, sa.10, 2011 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 15 Sayı: 10
Basım Tarihi: 2011
Doi Numarası: 10.1016/j.ijid.2011.05.019
Dergi Adı: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Kocaeli Üniversitesi Adresli: Evet

Özet

Background: The hepatitis B virus (HBV) polymerase (pol) gene completely overlaps with the envelope (S) gene. Mutations in the pol gene of HBV, either from selection of primary or secondary resistance mutations, typically result in changes in the overlapping hepatitis B surface antigen (HBsAg). Recent studies have conferred a new acronym to these HBV pol/S gene overlap mutants: ADAPVEMs, for antiviral drug-associated potential vaccine-escape mutants. The present study aimed to assess the prevalence and pattern of ADAPVEMs in Turkish patients with chronic hepatitis B (CHB).