Latent polyglandular autoimmune syndrome type 2 case diagnosed during a shock manifestation

Gurkan E., Cetinarslan B. , Guzelmansur I., Kocabas B.

GYNECOLOGICAL ENDOCRINOLOGY, vol.32, no.7, pp.521-523, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 7
  • Publication Date: 2016
  • Doi Number: 10.3109/09513590.2015.1137096
  • Page Numbers: pp.521-523


There are many types of polyglandular autoimmune syndrome (PAS). PAS type 2 is the most common type among adults. For PAS type 2 (PAS-2) diagnosis, detection of Addison's disease with autoimmune thyroid disease and/or type 1 diabetes mellitus are required. Premature ovarian insufficiency, pernicious anemia, vitiligo, alopecia, myasthenia gravis, celiac disease and autoimmune diabetes insipidus may be comorbidities of this condition. Contrary to the common belief, latent PAS is more common than the manifest forms. Here, we present a PAS-2 case diagnosed via adrenal crisis. At the time of diagnosis, the case was observed to have thyroid, adrenal and ovarian involvement. Therefore, PAS-2 and possible immunologic disorders were discussed.