The association between insulin-like growth factor 1 levels within reference range and early postoperative remission rate in patients with Cushing's disease

GEZER E. , Cetinarslan B. , SELEK A. , CANTÜRK Z. , SÖZEN M. , ELEN Ö. , ...Daha Fazla

ENDOCRINE RESEARCH, 2021 (SCI İndekslerine Giren Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası:
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1080/07435800.2021.1883056


Introduction: The relationship between growth hormone (GH)/insulin-like growth factor 1 (IGF-1) and glucocorticoids (GC) was examined in various studies. Long-term GC treatment was shown to decrease GH concentration and, interestingly, to increase IGF-1 concentration. We performed a retrospective study in order to examine how preoperative IGF-1 concentrations vary within the reference range and if tertiles of age- and sex-adjusted normal IGF-1 are predictive for early postoperative remission in the patients with Cushing's Disease (CD).