The association between insulin-like growth factor 1 levels within reference range and early postoperative remission rate in patients with Cushing's disease
ENDOCRINE RESEARCH, cilt.46, sa.3, ss.92-98, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 3
- Basım Tarihi: 2021
- Doi Numarası: 10.1080/07435800.2021.1883056
- Dergi Adı: ENDOCRINE RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.92-98
- Anahtar Kelimeler: Cushing's Disease, insulin-like growth factor 1, early postoperative remission
- Kocaeli Üniversitesi Adresli: Evet
Özet
Introduction: The relationship between growth hormone (GH)/insulin-like growth factor 1 (IGF-1) and glucocorticoids (GC) was examined in various studies. Long-term GC treatment was shown to decrease GH concentration and, interestingly, to increase IGF-1 concentration. We performed a retrospective study in order to examine how preoperative IGF-1 concentrations vary within the reference range and if tertiles of age- and sex-adjusted normal IGF-1 are predictive for early postoperative remission in the patients with Cushing's Disease (CD).