The association between insulin-like growth factor 1 levels within reference range and early postoperative remission rate in patients with Cushing's disease

GEZER E., Cetinarslan B., SELEK A., CANTÜRK Z., SÖZEN M., ELEN Ö., ...Daha Fazla

ENDOCRINE RESEARCH, cilt.46, sa.3, ss.92-98, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1080/07435800.2021.1883056
  • Dergi Adı: ENDOCRINE RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.92-98
  • Anahtar Kelimeler: Cushing's Disease, insulin-like growth factor 1, early postoperative remission
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Introduction: The relationship between growth hormone (GH)/insulin-like growth factor 1 (IGF-1) and glucocorticoids (GC) was examined in various studies. Long-term GC treatment was shown to decrease GH concentration and, interestingly, to increase IGF-1 concentration. We performed a retrospective study in order to examine how preoperative IGF-1 concentrations vary within the reference range and if tertiles of age- and sex-adjusted normal IGF-1 are predictive for early postoperative remission in the patients with Cushing's Disease (CD).