The effects of the immature rat model of febrile seizures on the occurrence of later generalized tonic-clonic and absence epilepsy

Ateş N., Akman Ö., Karson A.

Developmental Brain Research, vol.154, pp.137-140, 2005 (SCI-Expanded) identifier identifier identifier


This study was designed to investigate whether the intensity of experimental febrile seizures reduces the threshold to generalized tonic–clonic epilepsy and its effects on the development of generalized absence epilepsy in adulthood. For the evaluation of absence epilepsy, WAG/Rij rats and for the tonic–clonic seizures, PTZ injected Wistar rats were used. Our results showed that while the frequency of the experimental febrile seizures facilitates PTZ-induced generalized tonic–clonic seizures, it does not influence the properties of absence epileptic seizures in adulthood.