The effects of the immature rat model of febrile seizures on the occurrence of later generalized tonic-clonic and absence epilepsy

Ateş, NURBAY; Akman, Özlem; Karson, AYŞE

doi:10.1016/j.devbrainres.2004.10.001

The effects of the immature rat model of febrile seizures on the occurrence of later generalized tonic-clonic and absence epilepsy

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Ateş N., Akman Ö., Karson A.

Developmental Brain Research, vol.154, pp.137-140, 2005 (SCI-Expanded)

Publication Type: Article / Article
Volume: 154
Publication Date: 2005
Doi Number: 10.1016/j.devbrainres.2004.10.001
Journal Name: Developmental Brain Research
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.137-140
Kocaeli University Affiliated: Yes

Abstract

This study was designed to investigate whether the intensity of experimental febrile seizures reduces the threshold to generalized tonic–clonic epilepsy and its effects on the development of generalized absence epilepsy in adulthood. For the evaluation of absence epilepsy, WAG/Rij rats and for the tonic–clonic seizures, PTZ injected Wistar rats were used. Our results showed that while the frequency of the experimental febrile seizures facilitates PTZ-induced generalized tonic–clonic seizures, it does not influence the properties of absence epileptic seizures in adulthood.